MCAS: A POTS Connection

In the world of chronic illness, the connection between various conditions often presents a complex puzzle for both patients and medical professionals. Two such conditions that have been garnering increasing attention in recent years are Mast Cell Activation Syndrome (MCAS) and Postural Orthostatic Tachycardia Syndrome (POTS).

While distinct, these disorders share more than just symptoms; they often coexist within individuals, complicating diagnosis and treatment.

Understanding the connection between MCAS and POTS is important for those navigating the labyrinth of chronic illness, shedding light on shared mechanisms and potential avenues for management.

What are mast cells?

Mast cells are a type of white blood cell found in tissues throughout the body, particularly in areas like the skin, lungs, gastrointestinal tract, and mucous membranes. They play a role in the body's immune response, particularly in allergic reactions and inflammation. They can be activated by various triggers such as

• allergens (pollen, frangrances, foods, etc)
• pathogens (viruses, bacteria)
• physical injuries (cuts, scapes, or things more serious)

When activated, mast cells release a variety of chemical mediators, including histamine, prostaglandins, and cytokines. These mediators help to regulate the body's immune response, promote inflammation, and contribute to the symptoms associated with allergic conditions and other immune-related disorders.

Seasonal allergies are an example of mast cells most people experience.  When they work properly, mast cells will remove any foreign objects like pollen that may have entered our body.

Mast Cell Activation Syndrome (MCAS)

In people with MCAS, the mast cells become hyperactive, releasing excessive amounts of chemicals such as histamine and others in response to triggers that would typically be harmless. This heightened immune response can manifest in a myriad of symptoms affecting multiple organ systems, including skin rashes, gastrointestinal distress, respiratory issues, and symptoms like brain fog and headaches.

Common triggers for mast cell activation include

1. Environmental allergens (pollen, dust mites, pet dander)
2. Certain foods and food additives (artificial preservatives and additives)
3. Temperature extremes
4. Stress
5. Medications (especially NSAIDs, antibiotics, and opioids)
6. Exercise
7. Hormonal fluctuations

Risk factors for developing MCAS include genetic predisposition, environmental factors, and other underlying medical conditions such as autoimmune diseases or infections.

MCAS and Postural Orthostatic Tachycardia Syndrome (POTS)

POTS is characterized by an excessive increase in heart rate upon assuming an upright posture, often accompanied by symptoms such as dizziness, lightheadedness, fatigue, and cognitive difficulties. 

We know the POTS and MCAS are commonly diagnosed together, but more research is needed to be able to fully understand why the two conditions often go hand in hand.  Recognizing the common triggers and risk factors associated with MCAS, as well as understanding its connection to conditions like POTS, is essential for healthcare providers and patients alike. By unraveling these connections, we move closer to more effective management strategies and improved quality of life for those living with these challenging conditions.

Electrolytes for POTS Patients with MCAS

If you have POTS, you know that increased sodium intake and oral rehydration salts are often recommended to help manage your symptoms.  When it comes to MCAS, you never know what will end up being a trigger so trying something new can be scary.  We've got your back.

NormaLyte PURE was born for people just like you.  Containing no artificial sweeteners, no preservatives, no colors or dyes, and being gluten free NormaLyte is one of the safest options for you.  That is part of the reason we offer free samples to the public!  Claim them here and find out how NormaLyte can help you begin to manage symptoms of POTS while also being MCAS friendly.